Introduction: The goal of this article is to describe of the GIS application on Health and emphasize on position of GIS in Iran s Holistic Scientific map.Material and Methods: This article is a review of scientific and applicative studies done by domestic and foreign researchers that explain application of GIS on Health domain.Results: Applications of GIS in community Health and epidemiological study includes Crisis management at unexpected events, Spatial analysis in relation to incidence of diseases & environmental risk factors and exposures, Planning & implication of Health promotion program based on detection of geographically distribution of diseases and Early detection, evaluation and surveillance related to Bioterrorist Attacks and Conclusions: Holistic Scientific map will help to identify priority setting of researches, cooperation of researchers and is a pattern for scientific planning among that on Health. GIS is one of the new technologies that would help in easier and more precise collection of Health information and facilitating decision-making about Health care. Therefore, this domain can be considered by policy makers and Health managers.